PPPF Predictive Preventive Personalized Familial Care of Neurodiseases at KUH NeuroCenter

Publications Authored or Co-Authored by Our Present or Previous Staff with Our Collaborators

As of January 2016

Outcome After Subarachnoid Hemorrhage from Saccular Intracranial Aneurysm

Lång M, Raj R, Skrifvars MB, Koivisto T, Lehto H, Kivisaari R, von und zu Fraunberg M, Reinikainen M, Bendel S. Early moderate hyperoxemia does not predict outcome after aneurysmal subarachnoid hemorrhage. Neurosurgery 2015 (epub)

Huttunen J, Kurki MI, von und zu Fraunberg M, Koivisto T, Ronkainen A, Rinne J, Jääskeläinen JE, Kälviäinen R, Immonen A. Epilepsy after aneurysmal subarachnoid haemorrhage – a population based long-term follow up study. Neurology 2015

Adams H, Ban VS, Leinonen V, Aoun S, Huttunen J, Saavalainen T, Lindgren A, Frösén J, von und zu Fraunberg M, Koivisto T, Hernesniemi J, Welch B, Jääskeläinen JE, Huttunen T. Risk of Shunting After Aneurysmal Subarachnoid Hemorrhage: A Collaborative Study and Initiation of a Consortium. Stroke 2016

Huttunen J, Lindgren A, Kurki MI, Huttunen T, Frösen J, von und zu Fraunberg M, Koivisto T, Kälviäinen R, Räikkönen K, Viinamäki H, *Jääskeläinen JE, *Immonen A. Antidepressant Use After Aneurysmal Subarachnoid Hemorrhage: A Population-Based Case-Control Study. Stroke 2016

Huttunen T, von und Zu Fraunberg M, Koivisto T, Ronkainen A, Rinne J, Sankila R, Seppä K, Jääskeläinen JE. Long-term excess mortality of 244 familial and 1502 sporadic one-year survivors of aneurysmal subarachnoid hemorrhage compared with a matched Eastern Finnish catchment population. Neurosurgery 2011

Lehecka M, Niemelä M, Seppänen J, Lehto H, Koivisto T, Ronkainen A, Rinne J, Sankila R, Jääskeläinen J, Hernesniemi J. No long-term excess mortality in 280 patients with ruptured distal anterior cerebral artery aneurysms. Neurosurgery 2007

Ronkainen A, Niskanen M, Rinne J, Koivisto T, Hernesniemi J, Vapalahti M. Evidence for excess long-term mortality after treated subarachnoid hemorrhage. Stroke 2001

Karamanakos PN, von und zu Fraunberg M, Bendel S, Huttunen T, Kurki M, Hernesniemi J, Ronkainen A, Rinne J, Jaaskelainen JE, Koivisto T. Risk Factors for Three Phases of 12-Month Mortality in 1657 Patients from a Defined Population After Acute Aneurysmal Subarachnoid Hemorrhage. World Neurosurg 2012

Soppi V, Karamanakos PN, Koivisto T, Vanninen R, Jaaskelainen JE, Rinne J. A randomized outcome study of enteral versus intravenous nimodipine in 171 patients after acute aneurysmal subarachnoid hemorrhage. World Neurosurgery 2012

Soppi V, Kokki H, Koivisto T, Lehtonen M, Helin-Tanninen M, Lehtola S, Rinne  J. Early-phase pharmacokinetics of enteral and parenteral nimodipine in patients  with acute subarachnoid haemorrhage – a pilot study. Eur J Clin Pharmacol 2007

Karamanakos PN, Koivisto T, Vanninen R, Khallaf M, Ronkainen A, Parviainen I, Manninen H, von und zu Fraunberg M, Morgan MK, Jaaskelainen JE, Hernesniemi J, Rinne J. The impact of endovascular management on the outcome of aneurysmal subarachnoid hemorrhage in the elderly in Eastern Finland. Acta Neurochir 2010

van Munster CE, von und zu Fraunberg M, Rinkel GJ, Rinne J, Koivisto T, Ronkainen A. Differences in aneurysm and patient characteristics between cohorts of Finnish and Dutch patients with subarachnoid hemorrhage: time trends between 1986 and 2005. Stroke 2008

Mahindu A, Koivisto T, Ronkainen A, Rinne J, Assaad N, Morgan MK. Similarities and differences in aneurysmal subarachnoid haemorrhage between Eastern Finland and northern Sydney. J Clin Neurosci 2008

Bendel S, Koivisto T, Ryynänen OP, Ruokonen E, Romppanen J, Kiviniemi V, Uusaro A. Insulin like growth factor-I in acute subarachnoid hemorrhage: a prospective cohort study. Crit Care 2010

Bendel S, Koivisto T, Ruokonen E, Rinne J, Romppanen J, Vauhkonen I, Kiviniemi V, Uusaro A. Pituitary-adrenal function in patients with acute subarachnoid haemorrhage: a prospective cohort study. Crit Care 2008

Bendel P, Koivisto T, Aikiä M, Niskanen E, Könönen M, Hänninen T, Vanninen R. Atrophic enlargement of CSF volume after subarachnoid hemorrhage: correlation with neuropsychological outcome. AJNR Am J Neuroradiol 2010

Bendel P, Koivisto T, Niskanen E, Könönen M, Aikiä M, Hänninen T, Koskenkorva P, Vanninen R. Brain atrophy and neuropsychological outcome after treatment of ruptured anterior cerebral artery aneurysms: a voxel-based morphometric study. Neuroradiology 2009

Bendel P, Koivisto T, Könönen M, Hänninen T, Hurskainen H, Saari T, Vapalahti M, Hernesniemi J, Vanninen R. MR imaging of the brain 1 year after aneurysmal subarachnoid hemorrhage: randomized study comparing surgical with endovascular treatment. Radiology 2008

Bendel P, Koivisto T, Hänninen T, Kolehmainen A, Könönen M, Hurskainen H, Pennanen C, Vanninen R. Subarachnoid hemorrhage is followed by temporomesial volume loss: MRI volumetric study. Neurology 2006

Mustonen T, Koivisto T, Vanninen R, Hänninen T, Vapalahti M, Hernesniemi J, Kuikka JT, Vanninen E. Heterogeneity of cerebral perfusion 1 week after haemorrhage is an independent predictor of clinical outcome in patients with aneurysmal subarachnoid haemorrhage. J Neurol Neurosurg Psychiatry 2008

Liu Y, Soppi V, Mustonen T, Könönen M, Koivisto T, Koskela A, Rinne J, Vanninen RL. Subarachnoid hemorrhage in the subacute stage: elevated apparent diffusion coefficient in normal-appearing brain tissue after treatment. Radiology 2007

Mustonen T, Koivisto T, Vanninen E, Vanninen R, Kuikka JT. Cerebral perfusion heterogeneity and complexity in patients with acute subarachnoid haemorrhage. Nucl Med Commun 2006

Frösen J, Pitkäniemi J, Tulamo R, Marjamaa J, Isoniemi H, Niemelä M, Jääskeläinen J, Lokki ML, Matinlauri I. Association of fatal aneurysmal subarachnoid hemorrhage with human leukocyte antigens in the Finnish population. Hum Immunol 2007

Niskanen M, Koivisto T, Ronkainen A, Rinne J, Ruokonen E. Resource use after subarachnoid hemorrhage: comparison between endovascular and surgical treatment.  Neurosurgery 2004

Koivisto T, Vanninen E, Vanninen R, Kuikka J, Hernesniemi J, Vapalahti M. Cerebral perfusion before and after endovascular or surgical treatment of acutely ruptured cerebral aneurysms: a 1-year prospective follow-up study. Neurosurgery 2002

Koivisto T, Vapalahti M, Parviainen I, Takala J. Gastric tonometry after subarachnoid hemorrhage. Intensive Care Med 2001

Koivisto T, Vanninen R, Hurskainen H, Saari T, Hernesniemi J, Vapalahti M. Outcomes of early endovascular versus surgical treatment of ruptured cerebral aneurysms. A prospective randomized study. Stroke 2000

Vanninen R, Koivisto T, Saari T, Hernesniemi J, Vapalahti M. Ruptured intracranial aneurysms: acute endovascular treatment with electrolytically detachable coils–a prospective randomized study. Radiology 1999

Koivisto T, Vanninen E, Vanninen R, Saari T, Luukkonen M, Hernesniemi J, Vapalahti M. Regional cerebral blood flow in aneurysmal subarachnoid hemorrhage:  single photon emission tomography evaluation of endovascular versus surgical treatment. J Neurosurg Sci 1998

Phenotype and Dynamics of Saccular Intracranial Aneurysm Disease

Etminan N … Koivisto T… Macdonald RL. The unruptured intracranial aneurysm treatment score: a multidisciplinary consensus. Neurology 2015

Etminan N … Koivisto T … Macdonald RL. Multidisciplinary consensus on assessment of unruptured intracranial aneurysms: proposal of an international research group. Stroke 2014

Goehre F, Jahromi BR, Lehecka M, Lehto H, Kivisaari R, Andrade-Barazarte H, Ibrahim T, Párraga RG, Ludtka C, Meisel HJ, Koivisto T, von und zu Fraunberg M, Niemelä M, Jääskeläinen JE, Hernesniemi JA. Posterior Cerebral Artery Aneurysms: Treatment and Outcome Analyzes of 121 Patients. World Neurosurgery 2016

Lindgren AE, Koivisto T, Björkman J, von Und Zu Fraunberg M, Helin K, Jääskeläinen JE, Frösen J. Irregular Shape of Intracranial Aneurysm Indicates Rupture Risk Irrespective of Size in a Population-Based Cohort. Stroke 2016

Lindgren AE, Räisänen S, Tattari H, Björkman J, Huttunen J, Huttunen T, Kurki MI, Frösén J, Koivisto T, Jääskeläinen JE, von und zu Fraunberg M. De novo aneurysm formation in carriers of saccular intracranial aneurysm disease in Eastern Finland. Stroke 2016

Huttunen T, von und zu Fraunberg M, Frösen J, Lehecka M, Tromp G, Helin K, Koivisto T, Rinne J, Ronkainen A, Hernesniemi J, Jääskeläinen JE. Saccular intracranial aneurysm disease: distribution of site, size, and age suggests different etiologies for aneurysm formation and rupture in 316 familial and 1454 sporadic eastern Finnish patients. Neurosurgery 2010

Ronkainen A, Miettinen H, Karkola K, Papinaho S, Vanninen R, Puranen M, Hernesniemi J. Risk of harboring an unruptured intracranial aneurysm. Stroke 1998

Vanninen RL, Hernesniemi JA, Puranen MI, Ronkainen A. Magnetic resonance angiographic screening for asymptomatic intracranial aneurysms: the problem of false negatives: technical case report. Neurosurgery 1996

Rinne J, Hernesniemi J, Niskanen M, Vapalahti M. Analysis of 561 patients with 690 middle cerebral artery aneurysms: anatomic and clinical features as correlated to management outcome. Neurosurgery 1996

Rinne J, Hernesniemi J, Niskanen M, Vapalahti M. Management outcome for multiple intracranial aneurysms. Neurosurgery 1995

Rinne J, Hernesniemi J, Puranen M, Saari T. Multiple intracranial aneurysms in a defined population: prospective angiographic and clinical study. Neurosurgery 1994

Rinne JK, Hernesniemi JA. De novo aneurysms: special multiple intracranial aneurysms. Neurosurgery.1993

Concomitant Diseases in Saccular Intracranial Aneurysm Carriers

Lindgren AE, Kurki MI, Riihinen A, Koivisto T, Ronkainen A, Rinne J, Hernesniemi J, Eriksson JG, Jääskeläinen JE, von und zu Fraunberg M. Hypertension predisposes to the formation of saccular intracranial aneurysms in 467 unruptured and 1053 ruptured patients in Eastern Finland. Ann Med 2014

Lindgren AE, Kurki MI, Riihinen A, Koivisto T, Ronkainen A, Rinne J, Hernesniemi J, Eriksson JG, Jääskeläinen JE, von und zu Fraunberg M. Type 2 diabetes and risk of rupture of saccular intracranial aneurysm in Eastern Finland. Diabetes Care 2013

Pitkänen L, Tommila P, Kaarniranta K, Jääskeläinen JE, Kinnunen K. Retinal arterial macroaneurysms. Acta Ophthalmol 2013

Huttunen T, Riihinen A, Pukkala E, von und zu Fraunberg M, Koivisto T, Ronkainen A, Rinne J, Sankila R, Jääskeläinen JE. Increased relative risk of lung cancer in 2 904 patients with saccular intracranial aneurysm disease in Eastern Finland. Neuroepidemiology 2012

Lindgren A, Huttunen T, Saavalainen T, Riihinen A, Kurki MI, Koivisto T, Ronkainen A, Rinne J, Hernesniemi J, Jääskeläinen JE, von und zu Fraunberg M. Increased incidence of aneurysmal subarachnoid hemorrhage on Sundays and Mondays in 1862 patients from Eastern Finland. Neuroepidemiology 2011

Familial Saccular Intracranial Aneurysm Disease

Ronkainen A, Niskanen M, Piironen R, Hernesniemi J. Familial subarachnoid hemorrhage. Outcome study. Stroke 1999

Ronkainen A, Hernesniemi J, Puranen M, Niemitukia L, Vanninen R, Ryynänen M, Kuivaniemi H, Tromp G. Familial intracranial aneurysms. Lancet 1997

Ronkainen A, Hernesniemi J, Kuivaniemi H, Tromp G. Current implications for the efficacy of noninvasive screening for occult intracranial aneurysms in patients with a family history of aneurysms. J Neurosurg 1996

Ronkainen A, Hernesniemi J, Tromp G. Special features of familial intracranial aneurysms: report of 215 familial aneurysms. Neurosurgery 1995

Ronkainen A, Puranen MI, Hernesniemi JA, Vanninen RL, Partanen PL, Saari JT, Vainio PA, Ryynänen M. Intracranial aneurysms: MR angiographic screening in 400 asymptomatic individuals with increased familial risk. Radiology 1995

Ronkainen A, Hernesniemi J, Ryynänen M, Puranen M, Kuivaniemi H. A ten percent prevalence of asymptomatic familial intracranial aneurysms: preliminary report on 110 magnetic resonance angiography studies in members of 21 Finnish familial intracranial aneurysm families. Neurosurgery 1994

Ronkainen A, Hernesniemi J, Ryynänen M. Familial subarachnoid hemorrhage in east Finland 1977-1990. Neurosurgery 1993

Genomics of Saccular Intracranial Aneurysm Disease

Tatiana Foroud, Dongbing Lai, Daniel Koller, Femke van’t Hof, Mitja Kurki, Craig S Anderson, Robert D Brown Jr, E Sander Connolly, Johan G Eriksson, Matthew Flaherty, Myriam Fornage, Mikael von und zu Fraunberg, Emília I Gaál, Aki Laakso, Juha Hernesniemi, John Huston, Juha E Jääskeläinen, Lambertus A Kiemeney, Riku Kivisaari, Dawn Kleindorfer, Nerissa Ko, Hanna Lehto, Jason Mackey, Irene Meissner, Charles J Moomaw, Thomas H Mosley, Marek Moskala,  Mika Niemelä, Aarno Palotie, Joanna Pera, Gabriel Rinkel, Stephan Ripke,  Guy Rouleau, Ynte Ruigrok, Laura Sauerbeck, Agnieszka Słowik, Sita H Vermeulen, Daniel Woo, Bradford B Worrall, Joseph Broderick, for the FIA Study Investigators. Genome-wide association study of intracranial aneurysm identifies a new association on chromosome 7. Stroke 45:3194-9, 2014

van ‘t Hof FN, Kurki MI, Kleinloog R, de Bakker PI, von Und Zu Fraunberg M, Jääskeläinen JE, Gaál EI, Lehto H, Kivisaari R, Laakso A, Niemelä M, Hernesniemi J, Brouwer MC, van de Beek D, Rinkel GJ, Ruigrok YM. Genetic risk load according to the site of intracranial aneurysms. Neurology 83:34-39, 2014

van ‘t Hof FN, Ruigrok YM, Lee CH, Ripke S, Anderson G, de Andrade M, Baas AF, Blankensteijn JD, Böttinger EP, Bown MJ, Broderick J, Bijlenga P, Carrell DS, Crawford DC, Crosslin DR, Ebeling C, Eriksson JG, Fornage M, Foroud T, von Und Zu Fraunberg M, Friedrich CM, Gaál EI, Gottesman O, Guo DC, Harrison SC, Hernesniemi J, Hofman A, Inoue I, Jääskeläinen JE, Jones GT, Kiemeney LA, Kivisaari R, Ko N, Koskinen S, Kubo M, Kullo IJ, Kuivaniemi H, Kurki MI, Laakso A, Lai D, Leal SM, Lehto H, LeMaire SA, Low SK, Malinowski J, McCarty CA, Milewicz DM, Mosley TH, Nakamura Y, Nakaoka H, Niemelä M, Pacheco J, Peissig PL, Pera J, Rasmussen-Torvik L, Ritchie MD, Rivadeneira F, van Rij AM, Santos-Cortez RL, Saratzis A, Slowik A, Takahashi A, Tromp G, Uitterlinden AG, Verma SS, Vermeulen SH, Wang GT; Aneurysm  Consortium; Vascular Research Consortium of New Zealand, Han B, Rinkel GJ, de Bakker PI. Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms. J Am Heart Assoc 2016

Kurki MI, Emilia I. Gaál, Johannes Kettunen, Tuuli Lappalainen, Androniki Menelaou, Verneri Anttila, Femke N. van’t Hof, Mikael von und zu Fraunberg, Seppo Helisalmi, Mikko Hiltunen, Hanna Lehto, Aki Laakso, Riku Kivisaari, Timo Koivisto, Antti Ronkainen, Jaakko Rinne, Lambertus A.L. Kiemeney, Sita H. Vermeulen, Mari A. Kaunisto, Johan G. Eriksson, Arpo Aromaa, Markus Perola, Terho Lehtimäki, Olli T. Raitakari, Veikko Salomaa, Murat Gunel, Emmanouil T. Dermitzakis, Ynte M. Ruigrok, Gabriel J.E. Rinkel, Mika Niemelä, Juha Hernesniemi, Samuli Ripatti, Paul I.W. de Bakker, *Aarno Palotie, *Juha E. Jääskeläinen. High risk population isolate reveals low frequency variants predisposing to intracranial aneurysms. PLoS Genet 2014

Gaál EA, Salo P, Kristiansson K, Rehnström K,  Kettunen J, Niemelä M, Nieminen MS, Sinisalo J, Lokki M-L, Jula A, Raitakari O, Lehtimäki T, Eriksson JG, Widen E, Günel M, Kurki M, von und zu Fraunberg M, Jääskeläinen JE, Hernesniemi J, The International Consortium for Blood Pressure Genome-wide Association Studies (ICBP-GWAS), Palotie A, Salomaa V, Perola M. Intracranial Aneurysm risk locus 5q23·2 is associated with elevated systolic blood pressure. PloS Genet 2012 

Yasuno K, Bakircioglu M, Low S-K, Bilguvar K, Gaál E, Ruigrok YM, Niemela M, Hata A, Bijlenga P, Kasuya H, Jääskeläinen JE, Krex D, Auburger G, Simon M, Krischek B, Ozturk AK, Mane S, Steinmetz H, Zembutsu H, Inoue I, Palotie A, Cambien F, Nakamura Y, Lifton RP, Murat Günel M. A common variant near the endothelin receptor type A (EDNRA) gene is associated with intracranial aneurysm risk. Proc Natl Acad Sci USA 2011

Kurki MI, Paananen J, Storvik M, Ylä-Herttuala S, Jääskeläinen JE, von und zu Fraunberg M, Wong G, Pehkonen P. TAFFEL: Independent Enrichment Analysis of gene sets. BMC Bioinformatics 2011

Leu M, Humphreys K, Surakka I, Rehnberg E, Muilu J, Rosenström P, Almgren P, Jääskeläinen J, Lifton RP, Kyvik KO, Kaprio J, Pedersen NL, Palotie A, Hall P, Grönberg H, Groop L, Peltonen L, Palmgren J, Ripatti S. NordicDB: a Nordic pool and portal for genome-wide control data. Eur J Hum Genet 2010

Yasuno K, Bilguvar K, Bijlenga P, Low SK, Krischek B, Auburger G, Simon M, Krex D, Arlier Z, Nayak N, Ruigrok YM, Niemelä M, Tajima A, von und zu Fraunberg  M, Dóczi T, Wirjatijasa F, Hata A, Blasco J, Oszvald A, Kasuya H, Zilani G, Schoch B, Singh P, Stüer C, Risselada R, Beck J, Sola T, Ricciardi F, Aromaa A, Illig T, Schreiber S, van Duijn CM, van den Berg LH, Perret C, Proust C, Roder C, Ozturk AK, Gaál E, Berg D, Geisen C, Friedrich CM, Summers P, Frangi AF, State MW, Wichmann HE, Breteler MM, Wijmenga C, Mane S, Peltonen L, Elio V, Sturkenboom MC, Lawford P, Byrne J, Macho J, Sandalcioglu EI, Meyer B, Raabe A, Steinmetz H, Rüfenacht D, Jääskeläinen JE, Hernesniemi J, Rinkel GJ, Zembutsu H, Inoue I, Palotie A, Cambien F, Nakamura Y, Lifton RP, Günel M. Genome-wide association study of intracranial aneurysm identifies three new risk loci. Nat Genet 2010

Bilguvar K, Yasuno K, Niemelä M, Ruigrok YM, von Und Zu Fraunberg M, van Duijn CM, van den Berg LH, Mane S, Mason CE, Choi M, Gaál E, Bayri Y, Kolb L, Arlier Z, Ravuri S, Ronkainen A, Tajima A, Laakso A, Hata A, Kasuya H, Koivisto T, Rinne J, Ohman J, Breteler MM, Wijmenga C, State MW, Rinkel GJ, Hernesniemi J, Jääskeläinen JE, Palotie A, Inoue I, Lifton RP, Günel M. Susceptibility loci for intracranial aneurysm in European and Japanese populations. Nat Genet 2008

Helgadottir A, Thorleifsson G, Magnusson KP, Grétarsdottir S, Steinthorsdottir V, Manolescu A, Jones GT, Rinkel GJ, Blankensteijn JD, Ronkainen A, Jääskeläinen JE, Kyo Y, Lenk GM, Sakalihasan N, Kostulas K, Gottsäter A, Flex A, Stefansson H, Hansen T, Andersen G, Weinsheimer S, Borch-Johnsen K, Jorgensen  T, Shah SH, Quyyumi AA, Granger CB, Reilly MP, Austin H, Levey AI, Vaccarino V, Palsdottir E, Walters GB, Jonsdottir T, Snorradottir S, Magnusdottir D, Gudmundsson G, Ferrell RE, Sveinbjornsdottir S, Hernesniemi J, Niemelä M, Limet R, Andersen K, Sigurdsson G, Benediktsson R, Verhoeven EL, Teijink JA, Grobbee DE, Rader DJ, Collier DA, Pedersen O, Pola R, Hillert J, Lindblad B, Valdimarsson EM, Magnadottir HB, Wijmenga C, Tromp G, Baas AF, Ruigrok YM, van Rij AM, Kuivaniemi H, Powell JT, Matthiasson SE, Gulcher JR, Thorgeirsson G, Kong A, Thorsteinsdottir U, Stefansson K. The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nat Genet 2008

Weinsheimer S, Goddard KA, Parrado AR, Lu Q, Sinha M, Lebedeva ER, Ronkainen A, Niemelä M, Khusnutdinova EK, Khusainova RI, Helin K, Jääskeläinen JE, Sakovich VP, Land S, Kuivaniemi H, Tromp G. Association of kallikrein gene polymorphisms with intracranial aneurysms. Stroke 2007

van der Voet M, Olson JM, Kuivaniemi H, Dudek DM, Skunca M, Ronkainen A, Niemelä M, Jääskeläinen J, Hernesniemi J, Helin K, Leinonen E, Biswas M, Tromp G. Intracranial aneurysms in Finnish families: confirmation of linkage and refinement of the interval to chromosome 19q13.3. Am J Hum Genet 2004

Wills S, Ronkainen A, van der Voet M, Kuivaniemi H, Helin K, Leinonen E, Frösen J, Niemela M, Jääskeläinen J, Hernesniemi J, Tromp G. Familial intracranial aneurysms: an analysis of 346 multiplex Finnish families. Stroke 2003

Biology of Intracranial Aneurysm Wall (Dr J Frösén with Helsinki Neurosurgery IA Group and Biobank)

Marbacher S, Frösén J, Marjamaa J, Anisimov A, Honkanen P, von Gunten M, Abo-Ramadan U, Hernesniemi J, Niemelä M. Intraluminal cell transplantation prevents growth and rupture in a model of rupture-prone saccular aneurysms. Stroke 2014

Marbacher S, Marjamaa J, Abdelhameed E, Hernesniemi J, Niemelä M, Frösen J. The Helsinki rat microsurgical sidewall aneurysm model. J Vis Exp 2014

Cebral J, Ollikainen E, Chung BJ, Mut F, Sippola V, Jahromi BR, Tulamo R, Hernesniemi J, Niemelä M, Robertson A, Frösen J. Flow Conditions in the Intracranial Aneurysm Lumen Are Associated with Inflammation and Degenerative Changes of the Aneurysm Wall. AJNR Am J Neuroradiol. 2016.

Frösen J. Flow Dynamics of Aneurysm Growth and Rupture: Challenges for the Development of Computational Flow Dynamics as a Diagnostic Tool to Detect Rupture-Prone Aneurysms. Acta Neurochir Suppl. 2016

Ollikainen E, Tulamo R, Lehti S, Lee-Rueckert M, Hernesniemi J, Niemelä M, Ylä-Herttuala S, Kovanen PT, Frösen J. Smooth Muscle Cell Foam Cell Formation, Apolipoproteins, and ABCA1 in Intracranial Aneurysms: Implications for Lipid Accumulation as a Promoter of Aneurysm Wall Rupture. J Neuropathol Exp Neurol. 2016

Ollikainen E, Tulamo R, Frösen J, Lehti S, Honkanen P, Hernesniemi J, Niemelä  M, Kovanen PT. Mast cells, neovascularization, and microhemorrhages are associated with saccular intracranial artery aneurysm wall remodeling. J Neuropathol Exp Neurol 2014

Honkanen P, Frösen JK, Abo-Ramadan U, Hernesniemi JA, Niemelä MR. Visualization of luminal thrombosis and mural Iron accumulation in giant aneurysms with Ex vivo 4.7T magnetic resonance imaging. Surg Neurol Int 2014

Frösen J. Smooth muscle cells and the formation, degeneration, and rupture of saccular intracranial aneurysm wall–a review of current pathophysiological knowledge. Transl Stroke Res 2014

Frösen J, Tulamo R, Heikura T, Sammalkorpi S, Niemelä M, Hernesniemi J, Levonen AL, Hörkkö S, Ylä-Herttuala S. Lipid accumulation, lipid oxidation, and low plasma levels of acquired antibodies against oxidized lipids associate with degeneration and rupture of the intracranial aneurysm wall. Acta Neuropathol Commun 2013

Marbacher S, Marjamaa J, Bradacova K, von Gunten M, Honkanen P, Abo-Ramadan U, Hernesniemi J, Niemelä M, Frösen J. Loss of mural cells leads to wall degeneration, aneurysm growth, and eventual rupture in a rat aneurysm model. Stroke 2014

Laaksamo E, Tulamo R, Liiman A, Baumann M, Friedlander RM, Hernesniemi J, Kangasniemi M, Niemelä M, Laakso A, Frösen J. Oxidative stress is associated with cell death, wall degradation, and increased risk of rupture of the intracranial aneurysm wall. Neurosurgery 2013

Laaksamo E, Ramachandran M, Frösen J, Tulamo R, Baumann M, Friedlander RM, Harbaugh RE, Hernesniemi J, Niemelä M, Raghavan ML, Laakso A. Intracellular signaling pathways and size, shape, and rupture history of human intracranial aneurysms. Neurosurgery. 2012

Frösen J, Tulamo R, Paetau A, Laaksamo E, Korja M, Laakso A, Niemelä M, Hernesniemi J. Saccular intracranial aneurysm: pathology and mechanisms. Acta Neuropathol 2012

Kurki MI, Häkkinen SK, Frösen J, Tulamo R, von und zu Fraunberg M, Wong G, Tromp G, Niemelä M, Hernesniemi J, Jääskeläinen JE, Ylä-Herttuala S. Upregulated  signaling pathways in ruptured human saccular intracranial aneurysm wall: an emerging regulative role of Toll-like receptor signaling and nuclear factor-κB, hypoxia-inducible factor-1A, and ETS transcription factors. Neurosurgery 2011

Tulamo R, Frösen J, Paetau A, Seitsonen S, Hernesniemi J, Niemelä M, Järvelä  I, Meri S. Lack of complement inhibitors in the outer intracranial artery aneurysm wall associates with complement terminal pathway activation. Am JPathol 2010

Tulamo R, Frösen J, Hernesniemi J, Niemelä M. Inflammatory changes in the aneurysm wall: a review. J Neurointerv Surg 2010

Tulamo R, Frösen J, Junnikkala S, Paetau A, Kangasniemi M, Peláez J, Hernesniemi J, Niemelä M, Meri S. Complement system becomes activated by the classical pathway in intracranial aneurysm walls. Lab Invest 2010

Marjamaa J, Tulamo R, Frösen J, Abo-Ramadan U, Hernesniemi JA, Niemelä MR, Kangasniemi M. Occlusion of neck remnant in experimental rat aneurysms after treatment with platinum- or polyglycolic-polylactic acid-coated coils. Surg Neurol 2009

Tulamo R, Frösen J, Junnikkala S, Paetau A, Pitkäniemi J, Kangasniemi M, Niemelä M, Jääskeläinen J, Jokitalo E, Karatas A, Hernesniemi J, Meri S. Complement activation associates with saccular cerebral artery aneurysm wall degeneration and rupture. Neurosurgery 2006;59:1069-76

Frösen J, Marjamaa J, Myllärniemi M, Abo-Ramadan U, Tulamo R, Niemelä M, Hernesniemi J, Jääskeläinen J. Contribution of mural and bone marrow-derived neointimal cells to thrombus organization and wall remodeling in a microsurgical  murine saccular aneurysm model. Neurosurgery 2006

Frösen J, Piippo A, Paetau A, Kangasniemi M, Niemelä M, Hernesniemi J, Jääskeläinen J. Growth factor receptor expression and remodeling of saccular cerebral artery aneurysm walls: implications for biological therapy preventing rupture. Neurosurgery 2006

Marjamaa J, Tulamo R, Abo-Ramadan U, Hakovirta H, Frösen J, Rahkonen O, Niemelä M, Bornstein P, Penttinen R, Kangasniemi M. Mice with a deletion in the first intron of the Col1a1 gene develop dissection and rupture of aorta in the absence of aneurysms: high-resolution magnetic resonance imaging, at 4.7 T, of the aorta and cerebral arteries. Magn Reson Med 2006

Frösen J, Piippo A, Paetau A, Kangasniemi M, Niemelä M, Hernesniemi J, Jääskeläinen J. Remodeling of saccular cerebral artery aneurysm wall is associated with rupture: histological analysis of 24 unruptured and 42 ruptured cases. Stroke 2004

Endovascular Surgery of Intracranial Aneurysms

Tähtinen OI, Manninen HI, Vanninen RL, Rautio R, Haapanen A, Seppänen J, Niskakangas T, Rinne J, Keski-Nisula L. Stent-assisted embolization of recurrent  or residual intracranial aneurysms. Neuroradiology 2013

Tähtinen OI, Manninen HI, Vanninen RL, Seppänen J, Niskakangas T, Rinne J, Keski-Nisula L. The silk flow-diverting stent in the endovascular treatment of complex intracranial aneurysms: technical aspects and midterm results in 24 consecutive patients. Neurosurgery 2012

Tähtinen OI, Vanninen RL, Manninen HI, Rautio R, Haapanen A, Niskakangas T, Rinne J, Keski-Nisula L. Wide-necked intracranial aneurysms: treatment with stent-assisted coil embolization during acute (<72 hours) subarachnoid hemorrhage – experience in 61 consecutive patients. Radiology 2009

Vanninen R, Manninen H, Ronkainen A. Broad-based intracranial aneurysms: thrombosis induced by stent placement. AJNR Am J Neuroradiol 2003

Sturaitis MK, Rinne J, Chaloupka JC, Kaynar M, Lin Z, Awad IA. Impact of Guglielmi detachable coils on outcomes of patients with intracranial aneurysms treated by a multidisciplinary team at a single institution. J Neurosurg 2000

Microsurgery of Intracranial Aneurysms by Location – Helsinki Neurosurgery Series

(Clinical Data from Kuopio Intracranial Aneurysm Database)

Andrade-Barazarte H, Luostarinen T, Goehre F, Kivelev J, Jahromi BR, Ludtka C, Lehto H, Raj R, Ibrahim TF, Niemela M, Jääskeläinen JE, Hernesniemi JA. Transient cardiac arrest induced by adenosine: A tool for contralateral clipping of internal carotid artery-ophthalmic segment aneurysms. World Neurosurg 2015

Andrade-Barazarte H, Kivelev J, Goehre F, Jahromi BR, Noda K, Ibrahim TF, Kivisaari R, Lehto H, Jääskeläinen JE, Niemela M, Hernesniemi JA. Contralateral Approach to Bilateral Middle Cerebral Artery Aneurysms: Comparative Study, Angiographic Analysis, and Surgical Results. Neurosurgery 2015

Andrade-Barazarte H, Kivelev J, Goehre F, Jahromi BR, Hijazy F, Moliz N, Gauthier A, Kivisaari R, Jääskeläinen JE, Lehto H, Hernesniemi JA. Contralateral Approach to Internal Carotid Artery Ophthalmic Segment Aneurysms: Angiographic Analysis and Surgical Results for 30 Patients. Neurosurgery 2015

Goehre F, Lehecka M, Jahromi BR, Lehto H, Kivisaari R, Hijazy F, Nayeb L, Sugimoto T, Morishige M, Elsharkawy A, von Und Zu Fraunberg M, Jääskeläinen JE, Hernesniemi JA. Subtemporal Approach to Posterior Cerebral Artery Aneurysms. World Neurosurg 2015

Goehre F, Jahromi BR, Hernesniemi JA, Elsharkawy A, Kivisaari R, von und zu Fraunberg M, Jääskeläinen JE, Lehto H, Lehecka M. Characteristics of posterior cerebral artery (PCA) aneurysms: an angiographic analysis of 93 aneurysms in 81 patients. Neurosurgery 2014

Jahromi BR, Frösen J, Hernesniemi J. Commentary: Bypass Surgery for the Treatment of Dolichoectatic Basilar Trunk Aneurysms: A Work in Progress. Neurosurgery. 2016

Frösen J, Jahromi BR, Hernesniemi J. Intracerebral Hemorrhage as a Surgical Challenge-Where Should We Focus? World Neurosurg. 2016

Raj R, Bendel S, Reinikainen M, Hoppu S, Luoto T, Ala-Kokko T, Tetri S, Laitio R, Koivisto T, Rinne J, Kivisaari R, Siironen J, Skrifvars MB. Traumatic brain injury patient volume and mortality in neurosurgical intensive care units: a Finnish nationwide study. Scand J Trauma Resusc Emerg Med. 2016

Romani R, Lehto H, Laakso A, Horcajadas A, Kivisaari R, von und zu Fraunberg M, Niemelä M, Rinne J, Hernesniemi J. Microsurgery for previously coiled aneurysms: experience with 81 patients. Neurosurgery 2011

Lehecka M, Dashti R, Laakso A, van Popta JS, Romani R, Navratil O, Kivipelto L, Kivisaari R, Foroughi M, Kokuzawa J, Lehto H, Niemelä M, Rinne J, Ronkainen A, Koivisto T, Jääskelainen JE, Hernesniemi J. Microneurosurgical management of anterior choroid artery aneurysms. World Neurosurg 2010

Lehecka M, Dashti R, Romani R, Celik O, Navratil O, Kivipelto L, Kivisaari R, Shen H, Ishii K, Karatas A, Lehto H, Kokuzawa J, Niemelä M, Rinne J, Ronkainen A, Koivisto T, Jääskelainen JE, Hernesniemi J. Microneurosurgical management of internal carotid artery bifurcation aneurysms. Surg Neurol 2009

Lehecka M, Lehto H, Niemelä M, Juvela S, Dashti R, Koivisto T, Ronkainen A, Rinne J, Jääskeläinen JE, Hernesniemi JA. Distal anterior cerebral artery aneurysms: treatment and outcome analysis of 501 patients. Neurosurgery 2008

Lehecka M, Dashti R, Hernesniemi J, Niemelä M, Koivisto T, Ronkainen A, Rinne J, Jääskeläinen J. Microneurosurgical management of aneurysms at A4 and A5 segments and distal cortical branches of anterior cerebral artery. Surg Neurol 2008

Lehecka M, Dashti R, Hernesniemi J, Niemelä M, Koivisto T, Ronkainen A, Rinne J, Jääskeläinen J. Microneurosurgical management of aneurysms at A3 segment of anterior cerebral artery. Surg Neurol 2008

Lehecka M, Dashti R, Hernesniemi J, Niemelä M, Koivisto T, Ronkainen A, Rinne J, Jääskeläinen J. Microneurosurgical management of aneurysms at the A2 segment of anterior cerebral artery (proximal pericallosal artery) and its frontobasal branches. Surg Neurol 2008

Hernesniemi J, Dashti R, Lehecka M, Niemelä M, Rinne J, Lehto H, Ronkainen A, Koivisto T, Jääskeläinen JE. Microneurosurgical management of anterior communicating artery aneurysms. Surg Neurol 2008

Dashti R, Hernesniemi J, Lehto H, Niemelä M, Lehecka M, Rinne J, Porras M, Ronkainen A, Phornsuwannapha S, Koivisto T, Jääskeläinen JE. Microneurosurgical management of proximal anterior cerebral artery aneurysms. Surg Neurol 2007

Dashti R, Hernesniemi J, Niemelä M, Rinne J, Lehecka M, Shen H, Lehto H, Albayrak BS, Ronkainen A, Koivisto T, Jääskeläinen JE. Microneurosurgical management of distal middle cerebral artery aneurysms. Surg Neurol 2007

Dashti R, Hernesniemi J, Niemelä M, Rinne J, Porras M, Lehecka M, Shen H, Albayrak BS, Lehto H, Koroknay-Pál P, de Oliveira RS, Perra G, Ronkainen A, Koivisto T, Jääskeläinen JE. Microneurosurgical management of middle cerebral artery bifurcation aneurysms. Surg Neurol 2007

Dashti R, Rinne J, Hernesniemi J, Niemelä M, Kivipelto L, Lehecka M, Karatas A, Avci E, Ishii K, Shen H, Peláez JG, Albayrak BS, Ronkainen A, Koivisto T, Jääskeläinen JE. Microneurosurgical management of proximal middle cerebral artery aneurysms. Surg Neurol 2007

Hernesniemi J, Karatas A, Niemelä M, Ishii K, Shen H, Kivisaari R, Rinne J, Lehecka M, Kivipelto L. Aneurysms of the vertebral artery (VA). Zentralbl Neurochir  2005

Hernesniemi J, Niemelä M, Karatas A, Kivipelto L, Ishii K, Rinne J, Ronkainen A, Koivisto T, Kivisaari R, Shen H, Lehecka M, Frösen J, Piippo A, Jääskeläinen JE. Some collected principles of microneurosurgery: simple and fast, while preserving normal anatomy: a review. Surg Neurol 2005

Niskanen M, Koivisto T, Rinne J, Ronkainen A, Pirskanen S, Saari T, Vanninen R. Complications and postoperative care in patients undergoing treatment for unruptured intracranial aneurysms. J Neurosurg Anesthesiol 2005